Fluorescencein situhybridization for prenatal screening of chromosomal aneuploidies
نویسندگان
چکیده
منابع مشابه
P-226: Non-Invasive Prenatal Screening for Fetal Chromosomal Anomalies in South of Iran
Background: Prenatal diagnosis for Fetal Chromosomal anomalies currently relies on assessment of risk followed by a combination of biochemical and nuchal translucency. Trisomy 21 is the most common trisomy that is associated with intellectual disability. Pregnant women who receive a prenatal diagnosis of trisomy 21 currently have the option of continuing or terminating their pregnancy, but no f...
متن کاملApplication of proteomics to prenatal screening and diagnosis for aneuploidies.
Current screening for fetal aneuploidies relies on biochemical and ultrasound measurements, and the sensitivity and specificity needs to be improved to reduce the number of pregnant women subjected to invasive diagnostic procedures, such as amniocentesis. Proteomic technologies enable new strategies for discovering biomarkers from complex biological fluids in a high-throughput and sensitive man...
متن کاملQuantitative Fluorescence Polymerase Chain Reaction (QF-PCR) for Prenatal Diagnosis of Chromosomal Aneuploidies
Genomic aneuploidy is a common cause of human genetic disorders and cytogenetic analysis of metaphase karyotypes remain the standard method to identify aneuploidies and balanced translocations. Quantitative Fluorescence PCR (QF-PCR) is an alternative method in which DNA polymorphic markers on chromosomes, is used to determine the presence of different alleles. The assay based on the use of info...
متن کاملChromosomal Aneuploidies and Early Embryonic Developmental Arrest
Background Selecting the best embryo for transfer, with the highest chance of achieving a vital pregnancy, is a major goal in current in vitro fertilization (IVF) technology. The high rate of embryonic developmental arrest during IVF treatment is one of the limitations in achieving this goal. Chromosomal abnormalities are possibly linked with chromosomal arrest and selection against abnormal fe...
متن کاملInvestigation of QF-PCR Application for Rapid Prenatal Diagnosis of Chromosomal Aneuploidies in Iranian Population
OBJECTIVE G-Banding followed by standard chromosome analysis is routinely used for prenatal detection of chromosomal abnormalities. In recent years, molecular cytogenetic techniques have been developed for rapid diagnosis of chromosomal abnormalities. Among these methods Quantitative Florescence Polymerase Chain Reaction (QF-PCR) has been widely used for this purpose. Heterozygosity of short ta...
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ژورنال
عنوان ژورنال: Expert Review of Molecular Diagnostics
سال: 2008
ISSN: 1473-7159,1744-8352
DOI: 10.1586/14737159.8.4.355